My approach to investigating the mind integrates cognitive, affective, and contemplative science. A major implication of the basic science research I conducted as a graduate student and postdoc is that there is tremendous potential for beneficial psychological growth during adulthood, even in emotional domains often believed to be static personality traits. Now, as an Associate Scientist at the Center for Healthy Minds, University of Wisconsin-Madison, I am bridging basic and applied science to investigate psychological well-being as a skill. What skills underlie cultivating well-being and relieving suffering, and what are the best approaches to learning these skills? How do we improve scientific measurement of this kind of skill acquisition? Which skills are of most benefit to a given individual when taking into account life experience, sociocultural values, and other contextual factors?